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KMID : 1377020220190010177
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Tissue Engineering and Regenerative Medicine
2022 Volume.19 No. 1 p.177 ~ p.187
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Combined Mesenchymal Stem Cells and Cartilage Acellular Matrix Injection Therapy for Osteoarthritis in Goats
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Kim Mi-Jin
Ahn Jong-Chan
Lee Ju-Sik
Song Seong-Soo
Lee Seung-Hee
Kang Kyung-Sun
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Abstract
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Background: Human umbilical cord blood-derived MSCs (hUCB-MSCs) have been studied in osteoarthritis (OA) and cartilage regeneration. Our previous study demonstrated that hUCB-MSCs combined with cartilage acellular matrix injection (CAM Inj.) represent potential therapeutic agents for structural improvement and anti-inflammatory effects in a rabbit model of OA.
Methods: Based on a previous study, this study has evaluated the safety and efficacy of hUCB-MSCs combined with CAM Inj. in an anterior cruciate ligament transection (ACLT) with medial meniscectomy (MMx) in a goat model. In this study, 27 goats were divided into 5 groups: normal (n?=?3), OA (n?=?6), OA?+?CAM Inj. (n?=?6), OA?+?hUCB-MSCs (n?=?6), and OA?+?hUCB-MSCs?+?CAM Inj. (n?=?6). Lameness and radiographic parameters were assessed 6 months after administration, and macroscopic and histological evaluations of the goat articular cartilage were performed 6 months after intervention.
Results: The results showed significant improvement in lameness score only in the OA?+?hUCB-MSCs group at 5 months after treatment (*p?
Conclusion: In conclusion, treatment with a combination of hUCB-MSCs and CAM Inj. reduced OA symptoms and induced effective cartilage tissue repair in a goat model. We suggest the combination of hUCB-MSCs and CAM Inj. as an alternative therapy for OA.
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KEYWORD
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Osteoarthritis, Human umbilical cord blood-mesenchymal stem cells, Cartilage acellular matrix injection
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